Thermo Fisher Scientific Pannexin 2 Polyclonal Antibody
Thermo Fisher Scientific의 Pannexin 2 Polyclonal Antibody는 인간 PANX2 단백질의 N-말단 펩타이드(aa 57–106)에 특이적으로 반응하는 토끼 유래 IgG 항체입니다. WB 및 IHC에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 뇌 조직 연구 및 신경세포 간 통신 연구에 적합합니다.
- 카탈로그번호
- PA542245
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human PANX2 (aa 57–106) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2605925 |
Product Specific Information
Peptide sequence:
GTVLVPILLV TLVFTKNFAE EPIYCYTPHN FTRDQALYAR GYCWTELRDA
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rat: 100%
Zebrafish: 100%
Target Information
Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells of almost all types in mammalian tissues. They are absent only in adult skeletal muscle cells and some circulating blood cells.
A gap junction is formed by two hemichannels, one in each neighboring cell, composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are found only in chordates, while pannexins are present in both chordate and invertebrate genomes.
Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) appears to be a brain-specific gene and is abundantly expressed in the central nervous system. In many neuronal populations such as hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed; in other brain regions such as white matter, only pannexin 1-positive cells are found.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-42245_Pannexin_2_Q96RD6-3_Rabbit.svg, PA5-42245_Pannexin_2_Q96RD6-3_Rabbit_PDP.jpeg)
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