Thermo Fisher Scientific Pannexin 2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Peptide sequence:
GTVLVPILLV TLVFTKNFAE EPIYCYTPHN FTRDQALYAR GYCWTELRDA

Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rat: 100%
Zebrafish: 100%

Target Information

Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells of almost all types in mammalian tissues. They are absent only in adult skeletal muscle cells and some circulating blood cells.

A gap junction is formed by two hemichannels, one in each neighboring cell, composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are found only in chordates, while pannexins are present in both chordate and invertebrate genomes.

Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) appears to be a brain-specific gene and is abundantly expressed in the central nervous system. In many neuronal populations such as hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed; in other brain regions such as white matter, only pannexin 1-positive cells are found.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-42245_Pannexin_2_Q96RD6-3_Rabbit.svg, PA5-42245_Pannexin_2_Q96RD6-3_Rabbit_PDP.jpeg)