Thermo Fisher Scientific NLRP6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NALP6. Recombinant protein control fragment (Product #RP-97486). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NLRP6,uniProtId:P59044-1,ncbiNodeId:9606,antigenRange:734-836,antigenLength:892,antigenImageFileName:PA5-61758_NLRP6_P59044-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61758_NLRP6_P59044-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644457

Product Specific Information

Immunogen sequence: TLSHCKLPDA VCRDLSEALR AAPALTELGL LHNRLSEAGL RMLSEGLAWP QCRVQTVRVQ LPDPQRGLQY LVGMLRQSPA LTTLDLSGCQ LPAPMVTYLC AVL

Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 71%.

Target Information

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.