Thermo Fisher Scientific HOXA11 Polyclonal Antibody
HOXA11 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 다양한 종에서 높은 상동성을 보입니다. 합성 펩타이드 면역원 기반으로 제작되어 정확한 검출이 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific HOXA11 Polyclonal Antibody
Applications
- Western Blot (WB): Tested at 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human HOXA11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691323 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 85%; Zebrafish: 93%
Target Information
HOX11 (homeobox11 or Tcl-3) is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine and proline-rich amino terminus. HOX11 is essential for spleen development and cell survival, binding specific DNA sequences and localizing to the nucleus. It acts as a positive transcription activator for reporter genes linked to cis-regulatory elements.
HOX11 gene is highly expressed in T-ALLs due to translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11). These translocations deregulate the homeobox gene within the T-cell receptor locus, activating tumor-associated target genes. HOX11 gene translocation is associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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