Thermo Fisher Scientific RUNX1T1 Polyclonal Antibody
RUNX1T1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, Western blot에 최적화되어 있습니다. 인간 및 다양한 종에서 높은 상동성을 보이며, 급성 골수성 백혈병 연구에 유용합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human RUNX1T1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690883 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein.
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities.
This translocation produces a chimeric gene composed of the 5′ region of the RUNX1 gene fused to the 3′ region of the RUNX1T1 gene.
The resulting chimeric protein is believed to associate with the nuclear corepressor/histone deacetylase complex, thereby blocking hematopoietic differentiation.
Several transcript variants encoding multiple isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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