Thermo Fisher Scientific SCO2 Polyclonal Antibody
Human SCO2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500~1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤, 0.02% 아지드 포함)에서 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SCO2 (UniProt ID: O43819-1, aa 8–111) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647022 |
Product Specific Information
Immunogen sequence:
PTAWHRLSQL KPRVLPGTLG GQALHLRSWL LSRQGPAETG GQGQPQGPGL RTRLLITGLF GAGLGGAWLA LRAEKERLQQ QKRTEALRQA AVGQGDFHLL DHRG
Highest antigen sequence identity to the following orthologs:
- Mouse: 65%
- Rat: 26%
Target Information
Synthesis of cytochrome c oxidase 2 (SCO2) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.
Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cell lines, leads to a shift from normal aerobic respiration towards glycolytic ATP production.
Defects in the SCO2 protein are associated with fatal infantile cardioencephalomyopathy and COX deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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