Thermo Fisher Scientific NALP5 Polyclonal Antibody
Rabbit polyclonal antibody against human NALP5. Validated for IHC (paraffin) at 1:500–1:1,000 dilution. Antigen affinity purified, supplied in PBS with 40% glycerol. Suitable for research on apoptosis and neuronal injury mechanisms.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NALP5 (amino acids 399–513) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2644455 |
Product Specific Information
Immunogen sequence:
LLPESFLIVT VRDVGTEKLK SEVVSPRYLL VRGISGEQRI HLLLERGIGE HQKTQGLRAI MNNRELLDQC QVPAVGSLIC VALQLQDVVG ESVAPFNQTL TGLHAAFVFH QLTPR
Antigen sequence identity with orthologs:
- Mouse: 52%
- Rat: 50%
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins, which are involved in inflammation and reproduction.
NALP5 (also known as MATER) is a maternal gene required for early embryonic development in mice. Increased NALP5 expression has been observed in neuronal injury models. Transient expression of recombinant NALP5 in neurons induces caspase-3 activation and apoptosis, suggesting a role in neuronal apoptosis and potential relevance in neurodegenerative disorder research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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