Thermo Fisher Scientific TIP47 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunocytochemistry (ICC/IF)

• 10 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

TIP47 is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex.
Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex.
The encoded protein interacts with cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport.
It binds directly to GTPase RAB9, a member of the RAS oncogene family, increasing affinity for its cargo.
TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein.
Increased amounts are secreted into circulation of cervix carcinoma patients, suggesting significance as an oncodevelopmental marker.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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