Thermo Fisher Scientific MTCO1 Polyclonal Antibody
MTCO1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 합성 펩타이드 항원을 사용해 제작되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human COX1 (MTCO1, UniProt ID: P00395-1, antigen range: 422–451) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691631 |
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Cytochrome c oxidase subunit I (CO1 or MTCO1) is one of three mitochondrial DNA (mtDNA)-encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV.
Complex IV, located in the mitochondrial inner membrane, is the third and final enzyme of the electron transport chain involved in mitochondrial oxidative phosphorylation. It consists of 13 polypeptides: subunits I–III are mtDNA-encoded, while subunits IV–VIII are nuclear-encoded.
The cytochrome c oxidase family of enzymes contains four redox centers (two hemes and two copper centers). In mitochondrial Complex IV, the two hemes (a and a3) and CuB are bound to subunit I.
Research has shown that mutations in MTCO1 can impact enzyme function and mitochondrial respiratory efficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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