Thermo Fisher Scientific PCDHA3 Polyclonal Antibody
Rabbit polyclonal antibody against human PCDHA3. Validated for WB and IHC-P. Recognizes recombinant fragment (aa 22–238). Predicted cross-reactivity with mouse, rat, and chimpanzee. Supplied as liquid, 1 mg/mL, stored at 4°C or -20°C.
- 카탈로그번호
- PA531297
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 22–238 of Human PCDHA3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548771 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
- Predicted reactivity: Mouse (89%), Rat (89%), Chimpanzee (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PCDHA3 gene belongs to the protocadherin alpha gene cluster, one of three related clusters on chromosome 5 with a genomic organization similar to B-cell and T-cell receptor gene clusters.
This cluster includes 15 cadherin superfamily genes, consisting of 13 highly similar and 2 more distantly related coding sequences. The N-terminal variable exons encode six cadherin ectodomains, while the downstream constant exons encode the cytoplasmic domain.
These neural cadherin-like cell adhesion proteins are integral membrane proteins likely involved in establishing and maintaining specific cell-cell connections in the brain. Alternative splicing and additional variants have been observed, though their full-length forms remain undetermined.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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