Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody

Applications

ELISA

• Tested Dilution: 1:5,000 - 1:10,000

Product Specifications

Product Specific Information

• Stable at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• For extended storage, mix with an equal volume of glycerol, aliquot contents, and freeze at -20°C or below.

Target Information

Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of blood plasma proteins.
It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP and maintains partially unfolded proteins for refolding by other chaperones (e.g., HSPA8/HSC70).
Binding to cell surface receptors triggers internalization and degradation via lysosomal or proteasomal pathways.
Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis.
Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ligase complexes to promote ubiquitination and proteasomal degradation of target proteins (e.g., COMMD1, IKBKB).
Modulates NF-kappa-B transcriptional activity.
Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent cytochrome c release and inhibit apoptosis.
Plays a role in regulation of cell proliferation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.