Thermo Fisher Scientific CDIP1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
CLINDFKDVT HTCPSCKAYI YTYKLLC

Antigen sequence identity:
Mouse – 93%, Rat – 93%

Target Information

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers.
CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induces apoptosis in transfected cells, while siRNA suppression of caspase-8 mRNA blocks this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through the extrinsic cell death pathway.
CDIP may represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.