Thermo Fisher Scientific CDIP1 Polyclonal Antibody
CDIP1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol 완충액에 보관되며, 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDIP1 (Product #RP-101138) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639601 |
Product Specific Information
Immunogen sequence:
CLINDFKDVT HTCPSCKAYI YTYKLLC
Antigen sequence identity:
Mouse – 93%, Rat – 93%
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers.
CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induces apoptosis in transfected cells, while siRNA suppression of caspase-8 mRNA blocks this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through the extrinsic cell death pathway.
CDIP may represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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