Thermo Fisher Scientific PLD6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PLD6. Recombinant protein control fragment (Product #RP-90525). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PLD6,uniProtId:Q8N2A8-1,ncbiNodeId:9606,antigenRange:150-252,antigenLength:252,antigenImageFileName:PA5-61939_PLD6_Q8N2A8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61939_PLD6_Q8N2A8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645643

Product Specific Information

Immunogen sequence: QDPGYMHHKF AIVDKRVLIT GSLNWTTQAI QNNRENVLIT EDDEYVRLFL EEFERIWEQF NPTKYTFFPP KKSHGSCAPP VSRAGGRLLS WHRTCGTSSE SQT

Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 61%.

Target Information

PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.