Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (OX-8), PE
Flow Cytometry용 PE-결합 CD8 alpha 단클론 항체(OX-8). Rat 시료 반응성, Mouse IgG1 아이소타입. Protein G 정제, PBS+BSA 보존. 4°C 보관, 동결 금지. CD8 T세포 표지 및 면역세포 분석에 적합.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-8 |
| Immunogen | High molecular weight rat thymocyte glycoproteins |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538789 |
Additional Formats
- Unconjugated (MA1-70003)
- Biotin (MA5-17395)
- FITC (MA5-17397)
- PE-Cyanine5 (MA5-17401)
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, crucial for signal transduction and T cell activation. CD8 is mainly expressed on T cells as a heterodimer of CD8α and CD8β, acting as a co-receptor for MHC-I molecules. In contrast, CD4 interacts with MHC-II. CD8 also appears as homodimers of CD8α on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes triggers Lck recruitment, leading to cytokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in eliminating pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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