Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (OX-8), FITC
FITC 결합된 CD8 alpha 단일클론 항체(OX-8)로 랫트 시료에 반응하며, Flow Cytometry 및 IHC에 적합합니다. 고분자량 랫트 흉선 세포 당단백질을 면역원으로 사용하였으며, 단백질 G로 정제된 액상 형태입니다. 4°C 또는 -20°C에서 어둡게 보관합니다.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (OX-8), FITC
Applications
Immunohistochemistry (IHC)
Tested Dilution: -
View 1 publicationFlow Cytometry (Flow)
Tested Dilution: 0.5 µg/1x10^6 cells
View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-8 |
| Immunogen | High molecular weight rat thymocyte glycoproteins |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles; store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538787 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an essential role in signal transduction and T cell activation. CD8 is primarily expressed on T cells as a heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules. It is also found on subsets of NK cells, monocytes, and dendritic cells as homodimers of CD8α. Engagement of MHC-I/peptide complexes induces Lck recruitment, promoting cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are critical for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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