Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (AD4(15))
Thermo Fisher Scientific의 CD8 alpha Monoclonal Antibody (AD4(15))는 마우스 CD8a를 검출하는 IgM 형 단클론 항체입니다. Flow Cytometry에 최적화되어 있으며, 단백질 G 정제 및 PBS 버퍼에 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/1 million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AD4(15) |
| Immunogen | C57BL/6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073404 |
Additional Formats
Product Specific Information
- MA1-70077 detects CD8a in mouse samples.
- Successfully used in flow cytometry procedures.
- Immunogen: C57BL/6.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family involved in signal transduction and T cell activation.
CD8 is mainly expressed on T cells as a heterodimer (CD8α/CD8β) and functions as a co-receptor for MHC-I molecules.
It can also exist as a homodimer (CD8α/CD8α) on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are critical for pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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