Thermo Fisher Scientific Coagulation Factor VII/F7 Monoclonal Antibody (F7, 3516)
사람 Coagulation Factor VII 단백질을 인식하는 단클론 항체로, IHC 및 ELISA에 적합합니다. 마우스 IgG2a 아이소타입이며, Protein A/G로 정제된 액상 형태입니다. PBS(pH 7.4)에 보존제가 포함되지 않았으며, -20°C 이하에서 보관합니다.
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- 2155-MSM6-P1ABX
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Applications and Tested Dilution
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F7, 3516 |
| Immunogen | Recombinant fragment (around aa 366–466) of human F7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. It circulates in the blood as a zymogen and is activated by factor IXa, Xa, XIIa, or thrombin through minor proteolysis. Upon activation, it forms a heavy chain with a catalytic domain and a light chain with two EGF-like domains, connected by a disulfide bond. In the presence of factor III and calcium ions, the activated factor VII further activates the coagulation cascade by converting factor IX to IXa and/or factor X to Xa. Defects in F7 production can lead to coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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