Thermo Fisher Scientific CD244 Polyclonal Antibody
CD244 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD244 (Accession Q9BZW8), corresponding to amino acid residues I9–S59 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854568 |
Product Specific Information
Antibody detects endogenous levels of total CD244.
Target Information
CD244 (also known as 2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells and some T cells. It mediates non-major histocompatibility complex (MHC) restricted killing.
The interaction between NK-cell and target cells via CD244 modulates NK-cell cytolytic activity. CD244 interacts with SLAMF2, activating both SLAMF4- and SLAMF2-expressing cells.
Reduced SLAMF4 expression in NK cells and monocytes has been observed in patients with systemic lupus erythematosus, suggesting involvement in autoimmune pathology.
Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Alternatively spliced transcript variants encoding different isoforms of CD244 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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