Thermo Fisher Scientific PRL3 Polyclonal Antibody
PRL3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 보존. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTP4A3 (Accession O75365), corresponding to amino acid residues R137–M173. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854569 |
Product Specific Information
This antibody detects endogenous levels of total PTP4A3.
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which are cell signaling molecules involved in various regulatory processes. This class contains a PTP domain and a characteristic C-terminal prenylation motif. Studies in mice demonstrated that these proteins are prenylated in vivo, suggesting association with the plasma membrane. Overexpression in mammalian cells has been reported to inhibit angiotensin-II–induced calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression is upregulated in human liver carcinoma compared with normal liver and may contribute to colorectal cancer liver metastasis. PRL-3 is also expressed in tumor metastasis and vasculature regardless of tumor source.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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