Thermo Fisher Scientific POLR3D Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse.

Target Information

This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with the two most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in proteins that regulate cell growth, including tumor suppressor genes and proto-oncogenes. This protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting that formation of a stable complex between these proteins may be essential for BRCA1 tumor suppression. This protein may be a target of oncogenic mutations in breast or ovarian cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: A302-296A_POLR3D_P05423-1_Rabbit.svg, A302-296A_POLR3D_P05423-1_Rabbit_PDP.jpeg)