Thermo Fisher Scientific Phospho-PDGF Receptor beta (Tyr771) Polyclonal Antibody
PDGFRB 인산화 부위(Tyr771)를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Protein A로 정제된 액상 형태이며, -20°C에서 보관. 인간 PDGFRB 단백질의 인산화 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human PDGFRB around the phosphorylation site of Tyr771 [SN(p-Y)MA] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase involved in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The receptor can form homodimers or heterodimers with PDGFRA, depending on the ligand. The PDGFRB gene is located on chromosome 5, adjacent to the genes for GM-CSF and M-CSFR, and may be implicated in 5q syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) with ETV6 is associated with chronic myeloproliferative disorders with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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