Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/2949)
인간 Fibronectin을 인식하는 Mouse 모노클로날 항체로 ELISA 및 Peptide Array에 사용 가능. Recombinant fragment(aa 467-595)를 면역원으로 제작. 단일형 IgG1, kappa, Protein A/G 정제, PBS(pH 7.4) 용액 형태, 보존제 없음. 연구용 전용.
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Applications
ELISA
- Assay-dependent
Peptide Array
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FN1/2949 |
| Immunogen | Recombinant fragment (around aa 467-595) of human fibronectin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present as a soluble plasma protein.
Fibronectin is composed of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen and heparin), and cell receptors (e.g., integrins). It plays a crucial role in cell adhesion and migration processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression is increased in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to chemotherapy-induced apoptosis. The gene encoding Fibronectin undergoes alternative splicing, producing up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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