Thermo Fisher Scientific TGF beta-3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:10,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (97%), Rat (97%), Pig (87%), Chicken (86%), Rhesus Monkey (100%), Bovine (85%).
• Positive Control: mouse placenta, human TGFB3-transfected 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer.
TGF beta 3 is highly conserved across species, with mouse and human demonstrating 100% sequence homology and cross-species activity. Members of this family can be expressed by most cell types and exert pleiotropic effects, including suppression of B- and T-cell activity, mediation of tissue healing, and suppression of tumor proliferation.
Promotion of CD4+CD25+ T-cell expansion is a newly discovered function, indicating an important role in protection against autoimmunity.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.