Thermo Fisher Scientific SETD8 Monoclonal Antibody (OTI2F5), TrueMAB
SETD8 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로 인간 시료에 반응합니다. Western blot과 IHC(Paraffin)에서 검증되었습니다. 고순도 친화 크로마토그래피로 정제된 액상 항체로, 안정적인 PBS/BSA/glycerol buffer에 보관됩니다.
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Thermo Fisher Scientific SETD8 Monoclonal Antibody (OTI2F5), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Full length human recombinant protein of human SETD8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4.
H4 Lys-20 monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.
The protein mainly functions in euchromatin regions, playing a central role in silencing euchromatic genes.
It is required for cell proliferation, contributing to the maintenance of proper higher-order DNA structure during mitosis.
SETD8 is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrates compared to free histones.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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