Thermo Fisher Scientific CD8 Recombinant Rabbit Monoclonal Antibody (6J9V10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen Sequence:
SQFRVSPLDR TWNLGETVEL KCQVLLSNPT SGCSWLFQPR GAAASPTFLL YLSQNKPKAA EGLDTQRFSG KRLGDTFVLT LSDFRRENEG YYFCSALSNS IMYFSHFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC D

Target Information

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I (MHC-I) molecules.
Its counterpart, CD4, acts as a co-receptor for MHC-II molecules.
CD8α chain is essential for binding to MHC-I and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as disulfide-linked homodimers of CD8α.
Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs) triggers recruitment of lymphocyte-specific protein tyrosine kinase (Lck), leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.