Thermo Fisher Scientific CD153 Monoclonal Antibody (116614)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg per million cells

Neutralization (Neu)

• Tested Dilution: 1–4 µg/mL

Product Specifications

Product Specific Information

• In direct ELISAs, no cross-reactivity with recombinant human (rh) CD27 Ligand, recombinant mouse CD30 Ligand, or rhCD40 Ligand is observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.

Target Information

CD30 ligand (CD30L, also known as CD153) mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death.
CD30 plays a critical role in the pathophysiology of Hodgkin’s disease and other CD30+ lymphomas. It acts as a costimulatory molecule in thymic negative selection.
CD30 is expressed on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas (including Burkitt’s), virus-infected T and B cells, and activated normal T and B cells.
In T cells, CD30 expression is found in subsets producing Th2-type cytokines and on CD4+/CD8+ thymocytes coexpressing CD45RO and IL4 receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.