Thermo Fisher Scientific SP110 Monoclonal Antibody (OTI2A1)
SP110 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. 인간 반응성, Mouse IgG1 아이소타입. 액상 형태로 1 mg/mL 농도, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 232–521 of SP110 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725399 |
Target Information
Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component.
The protein functions as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator.
Alternative splicing has been observed for this gene, and three transcript variants encoding distinct isoforms have been identified.
SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/SP110 gene product may play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis.
IPR1/SP110 is upregulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.
Defects in SP110 cause severely impaired resistance to infection by M. tuberculosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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