Thermo Fisher Scientific Kindlin 3 Monoclonal Antibody (OTI2G2)
Kindlin 3 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. PBS buffer에 BSA, glycerol, sodium azide 포함. -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of FERMT3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724570 |
Target Information
The three KINDLINs are a novel family of focal adhesion proteins localizing to integrin adhesion sites. The KINDLIN proteins contain a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 are essential for integrin-mediated adhesion and spreading, while KINDLIN3 is restricted to hematopoietic cells, being abundant in megakaryocytes and platelets. Studies have shown misregulation of KINDLINs in various cancers, and KINDLIN3 is essential for platelet integrin activation and signaling, suggesting potential therapeutic targeting opportunities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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