Thermo Fisher Scientific SPAG1 Polyclonal Antibody
인간 SPAG1 단백질을 인식하는 토끼 폴리클로날 항체로, 면역조직화학(IHC-P)에서 1:500~1:1,000 희석 배율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 보존. 생식세포 및 정자막 단백질 연구에 적합.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC-P): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SPAG1. Recombinant protein control fragment: RP-103163 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647773 |
Product Specific Information
Immunogen sequence:
KKTPRDYAEW DKFDVEKECL KIDEDYKEKT VIDKSHLSKI ETRIDTAGLT EKEKDFLATR EKEKGNEAFN SGDYEEAVMY YT
Antigen sequence identity:
- Mouse: 86%
- Rat: 87%
Target Information
Anti-sperm antibodies have been correlated with unexplained infertility, suggesting a role in fertilization blockage. Identification of sperm antigens is crucial for improved diagnosis and treatment of immunologic infertility and for developing targeted contraception.
The SPAG1 protein localizes to the plasma membrane of germ cells in the testis and the post-acrosomal plasma membrane of mature spermatozoa. It binds GTP and exhibits GTPase activity, indicating a role in GTP signal transduction pathways involved in spermatogenesis and fertilization.
Two transcript variants encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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