Thermo Fisher Scientific Insulin Receptor Alpha Recombinant Rabbit Monoclonal Antibody (INSR, 2277R)
인슐린 수용체 알파에 특이적인 재조합 토끼 단클론 항체로, 인간 시료에서 반응성이 검증됨. IHC(P) 적용 가능하며, 고순도 Protein A/G 정제. HEK293 발현 시스템 사용, 액상 형태로 4°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- 3643-RBM2-P0
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | INSR, 2277R |
| Immunogen | Recombinant fragment of extracellular domain of human Insulin Receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of phosphorylation cascades.
Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins.
Defects in insulin receptor (IR) are associated with insulin resistance syndromes, while IGF-1R defects may cause growth retardation.
Both signaling cascades are important in cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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