Thermo Fisher Scientific HLA-DOA Polyclonal Antibody
HLA-DOA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 고순도 Affinity chromatography로 정제되어 안정적인 신호를 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: 참고문헌 보기
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: 참고문헌 보기
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HLA-DOA (Accession P06340), corresponding to amino acid residues A5–E55 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851067 |
Product Specific Information
Antibody detects endogenous levels of total HLA-DOA.
Target Information
Reacts with HLA-DO, a heterodimer formed by DNalpha and DObeta subunits in B cells. DNalpha and DObeta are the products of the non-classical class II genes, HLA-DNA and HLA-DOB, respectively.
DO forms tight complexes with DM in the endoplasmic reticulum and is thereby sorted to lysosomal vesicles during antigen processing and presentation. It is selectively expressed on antigen-presenting cells such as B cells, dendritic cells, and thymic epithelial cells.
DO enhances peptide loading efficiency and stabilizes DM at low pH, preserving its chaperon activity. DO–DM complexes are more efficient than DM alone in protecting empty DR molecules. Reports describe DO as a co-chaperone of DM.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-101633_HLA-DOA_P06340-1_Rabbit.svg, PA5-101633_HLA-DOA_P06340-1_Rabbit_PDP.jpeg)
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