Thermo Fisher Scientific PTGER2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PTGER2 (EP2 receptor). Validated for IHC (paraffin) with high species cross-reactivity. Antigen affinity purified, liquid form, 1 mg/mL concentration. Suitable for research use only, not for diagnostic applica...
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Thermo Fisher Scientific PTGER2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 6–15 µg/mL
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 3rd extracellular domain of human EP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550894 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Bat (100%)
Elephant, Bovine, Dog (94%)
Rat, Panda, Pig (88%)
Mouse (81%)
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 (PGE2) is one of five physiologically significant prostanoids. Its broad range of effects across immune, endocrine, cardiovascular, renal, and reproductive systems—as well as smooth muscle and brain tissue—is mediated through Prostaglandin E2 receptors (EP1, EP2, EP3, EP4).
EP2 receptors are 358 amino acid proteins with a short third intracellular loop. They stimulate adenylyl cyclase via coupling to Gs and do not undergo PGE2-induced internalization. EP2 receptors are involved in smooth muscle contraction and relaxation, primarily localized in lung, placental, and smooth muscle tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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