Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Recombinant Rabbit Monoclonal Antibody (PDCD1/7255R)
PDCD1/PD1/CD279 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체. 인간 시료 반응성, IHC 및 ELISA에 적합. HEK293 발현, Protein A/G 정제, 액상 형태로 제공. 4°C 보관, 연구용 전용.
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Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Recombinant Rabbit Monoclonal Antibody (PDCD1/7255R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDCD1/7255R |
| Immunogen | Recombinant fragment corresponding to extracellular domain of human PDCD1 protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express inhibitory receptors such as PD-1 (PDCD-1). PD-1 binds ligands PDL-1 and PDL-2, and upon binding, transmits inhibitory signals that suppress immune activation in the absence of danger signals such as LPS. PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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