Thermo Fisher Scientific L-Plastin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, Jurkat, Raji
• Predicted reactivity: Human (99%), Mouse (95%), Rat (94%), Zebrafish (84%), Xenopus laevis (89%), Chicken (90%), Rhesus Monkey (99%), Bovine (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

L-plastin is a leukocyte-specific actin bundling protein from the fimbrin family. It contains two actin-binding domains and two EF-hand calcium-binding domains. The protein is phosphorylated on a serine residue in its headpiece region in response to inflammatory stimuli. L-plastin is hypothesized to regulate integrin-mediated adhesion in leukocytes and is expressed in most human cancer cell lines derived from solid tumors. Its expression is upregulated by testosterone in androgen receptor-positive prostate and breast cancer cells through three androgen receptor binding elements in the upstream region of the gene.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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