Thermo Fisher Scientific CD8 Monoclonal Antibody (SP16)
CD8 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Monoclonal Antibody (SP16). 인간 시료에서 IHC(P), FACS 등에 사용 가능. 고순도 Protein A 정제, 안정적 PBS/BSA buffer 구성. 면역세포 활성 및 T세포 연구에 적합.
- 카탈로그번호
- MA514548
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CD8 Monoclonal Antibody (SP16)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 39 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 8 publications |
| Immunocytochemistry (ICC/IF) | - | View 7 publications |
| Flow Cytometry (Flow) | 1:1,000 | View 3 publications |
| in situ PLA (PLA) | - | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP16 |
| Immunogen | Synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 molecule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.022 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984334 |
Product Specific Information
MA5-14548 targets CD8 in IHC (P) and FACS applications and shows reactivity with Human samples.
The immunogen is a synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of the alpha chain of the CD8 molecule.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family. It plays an integral role in signal transduction, T cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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