Thermo Fisher Scientific TIN2 Polyclonal Antibody
TIN2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. 인간 시료에 반응하며, IHC(P) 및 Peptide ELISA에서 검증되었습니다. 고순도(Ammonium sulfate precipitation)로 정제되어 있으며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA5142176
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 3.75 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KENPVDLPATEQKE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932834 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
TRF1 is a negative regulator of telomere length maintenance. Recently, two proteins—tankyrase and Tin2—which bind to mammalian TRF1, have been identified.
Tankyrase has homology to ankyrins and the catalytic domain of poly(ADP-ribose) polymerase (PARP). It localizes to telomeres by binding to TRF1 through its ankyrin repeats and exhibits PARP activity.
ADP-ribosylation of TRF1 reduces its ability to bind telomeric DNA, suggesting that telomere function is regulated by poly(ADP)-ribosylation.
TIN2 was identified as a TRF1-interacting partner via yeast two-hybrid screening. It localizes to telomeres and is essential for proper telomere length regulation. Like TRF1, TIN2 is constitutively expressed, acting to counterbalance telomere elongation by telomerase, though endogenous levels may be low and difficult to visualize by immunostaining.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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