Thermo Fisher Scientific F8 Monoclonal Antibody (1E8)
Human F8 단백질을 인식하는 Mouse 단클론 항체(1E8)로 ELISA 및 in situ PLA에 적합. Affinity chromatography로 정제된 액상 형태이며, PBS(pH 7.4) 버퍼에 보존제 없이 제공. 연구용으로 혈액응고 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| ELISA | 3 ng/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E8 |
| Immunogen | F8 (NP_000123, 213 a.a. approximately 312 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
KFILLFAVFD EGKSWHSETK NSLMQDRDAA SARAWPKMHT VNGYVNRSLP GLIGCHRKSV YWHVIGMGTT PEVHSIFLEG HTFLVRNHRQ ASLEISPITF
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation. Factor VIII is a cofactor for factor IXa which, in the presence of Ca²⁺ and phospholipids, converts factor X to the activated form Xa.
This gene produces two alternatively spliced transcripts:
- Transcript variant 1 encodes isoform a, a large glycoprotein circulating in plasma and associated with von Willebrand factor.
- Transcript variant 2 encodes isoform b, a smaller protein consisting mainly of the phospholipid-binding domain essential for coagulant activity.
Defects in this gene result in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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