Thermo Fisher Scientific ZCCHC6 Polyclonal Antibody
인간 ZCCHC6 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZCCHC6. Recombinant protein control fragment (Product #RP-92886). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649836 |
Product Specific Information
Immunogen sequence:
DDYKGDKVYH PETGRKNEKE KVGRKGKHLL TVDQKRGEHV VCGSTRNNES ESTLDLEGFQ NPTAKECEGL ATLDNKADLD GESTEGTEEL EDSLNHFTHS VQGQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 38%
- Rat: 37%
Target Information
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, facilitating global mRNA decay. Essential for oocyte maturation and fertility.
Through 3′ terminal uridylation of mRNA, TUT7 and ZCCHC6 regulate maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA-induced gene silencing via uridylation of deadenylated miRNA targets.
Acts as a suppressor of miRNA biogenesis by mediating terminal uridylation of specific pre-miRNAs such as pre-let-7, preventing Dicer processing and promoting degradation.
In cooperation with LIN28A, enhances pre-let-7 uridylation.
TUT4 and TUT7 also restrict retrotransposition of LINE-1 elements by uridylating LINE-1 mRNAs, inhibiting reverse transcription and destabilizing cytoplasmic mRNAs.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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