Thermo Fisher Scientific DUSP8 Polyclonal Antibody
DUSP8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제 및 안정적 PBS/glycerol buffer 제공.
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Thermo Fisher Scientific DUSP8 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human DUSP8 (NP_0044112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855079 |
Product Specific Information
Immunogen sequence: NleAGDRLPR KVNl
Target Information
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the dual specificity phosphatase family show distinct substrate specificities for various MAP kinases, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is predominantly expressed in adult brain, heart, and skeletal muscle, localized in the cytoplasm, and induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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