Thermo Fisher Scientific TTLL12 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TTLL12. Recombinant protein control fragment (Product #RP-91500). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TTLL12,uniProtId:Q14166-1,ncbiNodeId:9606,antigenRange:507-636,antigenLength:644,antigenImageFileName:PA5-51810_TTLL12_Q14166-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51810_TTLL12_Q14166-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649095

Product Specific Information

Immunogen sequence: DYEKHFTVMN YDPDVVLKQV HCEEFIPEFE KQYPEFPWTD VQAEIFRAFT ELFQVACAKP PPLGLCDYPS SRAMYAVDLM LKWDNGPDGR RVMQPQILEV NFNPDCERAC RYHPTFFNDV FSTLFLDQPG

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 85%.

Target Information

TTLL12 (tubulin tyrosine ligase-like family, member 12) is a 644 amino acid protein that contains one TTL domain. Of the fourteen members of the TTLL family that modify tubulin, TTLL12 is the least characterized member. TTLL12 is highly expressed in a multitude of metastatic prostate cancer cell lines, therefore, it is considered a target for tumor therapy. Overexpression of TTLL12 is suggested to alter chromosome ploidy, whereas downregulation of TTLL12 influence several post-translational modifications of tubulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.