Thermo Fisher Scientific CAS Monoclonal Antibody (P5111)
CAS 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체. Western blot과 Immunocytochemistry에 최적화되어 있으며, 사람, 마우스, 랫트에 반응. Protein G 정제, 1 mg/mL 농도, PBS 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P5111 |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 222–469 of CSE1L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| RRID | AB_2539675 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2.
- Predicted reactivity: Mouse (99%), Rat (100%), Zebrafish (95%), Xenopus laevis (97%), Pig (100%), Rhesus Monkey (100%), Bovine (100%).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Proteins carrying a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The encoded protein binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by RANBP1 and RANGAP1. It may also play a role in apoptosis and cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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