Thermo Fisher Scientific TET2 Monoclonal Antibody (P411)
TET2 단백질을 인식하는 Mouse monoclonal antibody (Clone P411). Western blot 및 Immunoprecipitation에 적합. Human 시료에 반응하며, Protein G 정제. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P411 |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 429–637 of TET2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2539673 |
Product Specific Information
- Recommended positive controls: DDDDK-human TET2-transfected 293T
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), playing a key role in active DNA demethylation.
TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs and mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and 5fC to 5-carboxylcytosine (5caC).
These conversions likely constitute the first step in cytosine demethylation.
Additionally, TET2 is involved in recruiting O-GlcNAc transferase (OGT) to CpG-rich transcription start sites of active genes, promoting histone H2B GlcNAcylation by OGT.
Mutations in TET2 can result in Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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