Thermo Fisher Scientific ATF2 Polyclonal Antibody
인간 ATF2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 Flow Cytometry에 사용 가능. 합성 펩타이드 면역원으로 제작되었으며, Protein G로 정제됨. 0.5 mg/mL 농도의 액상 형태로 제공되며, 연구용으로 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Flow Cytometry (Flow) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 13–27 of human ATF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070501 |
Product Specific Information
Suggested positive control: 293 whole cell lysate.
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Various cellular stresses, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate ATF-2 transcriptional activity.
Phosphorylation at Thr69 and Thr71 activates ATF-2, mediated by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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