Thermo Fisher Scientific CETP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-493 of human CETP (NP_0000692) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CETP,uniProtId:P11597-1,ncbiNodeId:9606,antigenRange:300-493,antigenLength:493,antigenImageFileName:PA5-89297_CETP_P11597-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89297_CETP_P11597-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.07 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805475

Product Specific Information

Immunogen sequence: LMLSLMGDEF KAVLETWGFN TNQEIFQEVV GGFPSQAQVT VHCLKMPKIS CQNKGVVVNS SVMVKFLFPR PDQQHSVAYT FEEDIVTTVQ ASYSKKKLFL SLLDFQITPK TVSNLTESSS ESVQSFLQSM ITAVGIPEVM SRLEVVFTAL MNSKGVSLFD IINPEIITRD GFLLLQMDFG FPEHLLVDFL QSLS; Positive Samples: A-549, HepG2, A375, Mouse liver, Rat liver; Cellular Location: extracellular space

Target Information

It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.