Thermo Fisher Scientific TFAM Polyclonal Antibody
TFAM 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA, ChIP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 미토콘드리아 관련 연구에 유용합니다. 고순도 친화 크로마토그래피 정제 제품입니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TFAM Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| ChIP assay (ChIP) | 5 µg antibody for 10–15 µg of Chromatin |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human TFAM (NP_003192.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.83 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805476 |
Product Specific Information
Immunogen sequence:
QDAYRAEWQV YKEEISRFKE QLTPSQIMSL EKEIMDKHLK RKAMTKKKEL TLLGKPKRPR SAYNVYVAER FQEAKGDSPQ EKLKTVKENW KNLSDSEKEL Y
Positive Samples: SW620, HT-29
Cellular Location: Mitochondrion, Mitochondrion matrix, Mitochondrion nucleoid
Target Information
Mitochondrial transcription factor A (TFAM) is a nuclear-encoded protein that is imported into mitochondria, where it plays a key role in maintaining and expressing mitochondrial DNA (mtDNA). TFAM regulates mtDNA replication and transcription, ensuring proper mitochondrial function. It contains an LC3 interacting region (LIR) motif that allows binding to autophagy proteins such as LC3, facilitating the removal of leaked mtDNA and limiting inflammation. TFAM levels differ across tissues and influence oxidative phosphorylation (OXPHOS) capacity. Disruptions in TFAM function are linked to mitochondrial dysfunction and diseases associated with mtDNA stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.