Thermo Fisher Scientific Sirt1 Polyclonal Antibody
SIRT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성 제공. 인간 시료 반응성, 액상 형태로 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human Sirtuin (Silent Mating Type Information Regulation 2) type 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through deacetylation of histones and promotes alterations in histone and DNA methylation, leading to transcriptional repression.
It plays an essential role in skeletal muscle cell differentiation and mediates the inhibitory effect on skeletal myoblast differentiation under low nutrient conditions, involving AMPK and NAMPT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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