Thermo Fisher Scientific Myelin Basic Protein Monoclonal Antibody (MBP/4273)
Myelin Basic Protein(MBP)을 인식하는 Rat monoclonal antibody로 다양한 종에서 반응하며 Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능. Protein A/G로 정제된 액상 항체로, 4°C 보관 권장.
- 카탈로그번호
- 4155-RTM3-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Myelin Basic Protein Monoclonal Antibody (MBP/4273)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Fish, Guinea pig, Human, Mouse, Sheep, Pig, Rabbit, Rat |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MBP/4273 |
| Immunogen | Reacts with human MBP, recognizing epitopes in the 82–87 amino acid region (DENPVV) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also present in bone marrow and the immune system. These mRNAs arise from the long MBP gene (also called Golli-MBP), which contains three additional exons upstream of the classic MBP exons.
Alternative splicing from the Golli and MBP transcription start sites produces two sets of MBP-related transcripts and gene products. The Golli mRNAs contain three unique exons spliced in-frame to one or more MBP exons, encoding hybrid proteins with N-terminal Golli sequences linked to MBP sequences. The second family of transcripts contains only MBP exons and produces the well-characterized myelin basic proteins.
This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for gene function and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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