Thermo Fisher Scientific ARK5 Polyclonal Antibody
ARK5(NUAK1) 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 고순도 Protein A 정제 및 PBS/glycerol buffer로 안정화. 암 연구 및 세포 신호전달 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse NUAK1 protein, Lys404–Leu651 (Accession #Q641K5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091400 |
Target Information
NUAK1 (ARK5) is a serine/threonine kinase involved in various cellular processes. Overexpression is associated with tumor invasion and metastasis (e.g., colorectal cancer).
It regulates cellular senescence and ploidy by phosphorylating LATS1 at Ser-464, affecting its stability.
Also controls cell adhesion via the myosin protein phosphatase 1 (PP1) complex by phosphorylating PPP1R12A, which then binds 14-3-3 proteins to modulate myosin MLC2 dephosphorylation.
NUAK1 participates in the DNA damage response by phosphorylating p53 at Ser-15 and Ser-392, contributing to transcription activation.
It may promote tumor malignancy through AKT1-dependent phosphorylation, suppress Fas-induced apoptosis by phosphorylating CASP6, and regulate UV-induced DNA damage response via CDKN1A phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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