Thermo Fisher Scientific UBASH3A Polyclonal Antibody
UBASH3A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 반응성, Mouse·Dog·Bovine에 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기·-20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 40–316 of Human UBASH3A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548187 |
Product Specific Information
- Recommended positive control: K562
- Predicted reactivity: Mouse (86%), Dog (89%), Bovine (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized in both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain. TULA is highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes. It forms homodimers or homo-oligomers that interfere with receptor-type tyrosine kinase degradation, promoting accumulation of activated receptors on the cell surface. TULA is part of an EGFR- and Cbl-containing complex interacting with ubiquitinated proteins. The gene encoding TULA maps to human chromosome 21 and may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced via alternative splicing.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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