
Thermo Fisher Scientific WFS1 Polyclonal Antibody
Human WFS1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. Wolfram syndrome 관련 ER 스트레스 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WFS1. Recombinant protein control fragment (Product #RP-90661) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649642 |
Product Specific Information
- Immunogen sequence:
KHPCHIKKFD RYKFEITVGM PFSSGADGSR SREEDDVTKD IVLRASSEFK SVLLSLRQGS LIEFSTILEG RLGSKWPVFE LKAISCLNCM AQLSPTRRHV KIEHDW - Highest antigen sequence identity to orthologs:
Mouse - 88%, Rat - 88%
Target Information
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes.
It plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas.
Normally up-regulated during insulin secretion, while inactivation can cause ER stress.
Chronic ER stress is a major involvement in Wolfram syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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