Thermo Fisher Scientific Amyloid Beta 1-16 Monoclonal Antibody (Ab3)

Applications 및 권장 희석 배수

Product Specifications

Product Specific Information

This antibody recognizes Ab1–16 as well as other Ab peptides: Ab37, Ab38, Ab39, Ab40, and Ab42.
Note: When administered to young Tg2576 mice with minimal Ab deposition and to older mice with higher Ab loads, this antibody reduced Ab accumulation in the brain.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process:

1. Beta-secretase (BACE) cleaves the extracellular domain of beta APP, producing a membrane-bound remnant.
2. Gamma-secretase then cleaves the remnant, generating the amyloid beta peptide.

Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2 as central components, along with nicastrin, which binds to the carboxyl-terminus of beta APP and modulates Abeta production.
Abeta is an extracellular filamentous protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles.

Relevance:
Abnormal beta amyloid deposition is characteristic of Alzheimer’s disease and is also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.